Post mortem examination of Parkinson’s disease brains suggests decline in mitochondrial biomass, reversed by deep brain stimulation of subthalamic nucleus

All roads lead to mitochondria (it seems)—the “power house” of our cells. This paper suggests that DBS has a positive affect on mitochondrial volume in the brain region that houses dopamine cells. We know that DBS alters a number of physiologic parameters, and while it’s likely that changes in mitochondria are temporally downstream of the immediate therapeutic effects, it remains an interesting finding because of other theories regarding mitochondrial dysfunction and Parkinson’s disease.

Optogenetic Stimulation of Frontal D1 Neurons Compensates for Impaired Temporal Control of Action in Dopamine-Depleted Mice

A look at how D1 dopamine receptors might play a role in temporal processing (based on an action performed). Interestingly, a 2 Hz (delta band) stimulation improves performance.